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mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2.

Identifieur interne : 000953 ( Main/Exploration ); précédent : 000952; suivant : 000954

mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2.

Auteurs : Kyeongjin Kim [États-Unis] ; Li Qiang [États-Unis] ; Matthew S. Hayden [États-Unis] ; David P. Sparling [États-Unis] ; Nicole H. Purcell [États-Unis] ; Utpal B. Pajvani [États-Unis]

Source :

RBID : pubmed:26743335

Descripteurs français

English descriptors

Abstract

Mechanistic target of rapamycin complex 1 (mTORC1), defined by the presence of Raptor, is an evolutionarily conserved and nutrient-sensitive regulator of cellular growth and other metabolic processes. To date, all known functions of Raptor involve its scaffolding mTOR kinase with substrate. Here we report that mTORC1-independent ('free') Raptor negatively regulates hepatic Akt activity and lipogenesis. Free Raptor levels in liver decline with age and in obesity; restoration of free Raptor levels reduces liver triglyceride content, through reduced β-TrCP-mediated degradation of the Akt phosphatase, PHLPP2. Commensurately, forced PHLPP2 expression ameliorates hepatic steatosis in diet-induced obese mice. These data suggest that the balance of free and mTORC1-associated Raptor governs hepatic lipid accumulation, and uncover the potentially therapeutic role of PHLPP2 activators in non-alcoholic fatty liver disease.

DOI: 10.1038/ncomms10255
PubMed: 26743335
PubMed Central: PMC4729872


Affiliations:


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Le document en format XML

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<term>Blood Glucose (metabolism)</term>
<term>Blotting, Western (MeSH)</term>
<term>Chromatography, Gel (MeSH)</term>
<term>Diet, High-Fat (MeSH)</term>
<term>Fatty Liver (genetics)</term>
<term>Fatty Liver (metabolism)</term>
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<term>Chromatographie sur gel (MeSH)</term>
<term>Complexe-1 cible mécanistique de la rapamycine (MeSH)</term>
<term>Complexes multiprotéiques (MeSH)</term>
<term>Foie (métabolisme)</term>
<term>Glycémie (métabolisme)</term>
<term>Hépatocytes (métabolisme)</term>
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<term>Lipogenèse (génétique)</term>
<term>Obésité (génétique)</term>
<term>Obésité (métabolisme)</term>
<term>Phosphoprotein Phosphatases (métabolisme)</term>
<term>Protéine de régulation associée à mTOR (MeSH)</term>
<term>Protéine oncogène v-akt (métabolisme)</term>
<term>Protéines adaptatrices de la transduction du signal (génétique)</term>
<term>Protéines à répétitions de séquences bêta-transducine (métabolisme)</term>
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<term>Stéatose hépatique (métabolisme)</term>
<term>Stéatose hépatique non alcoolique (génétique)</term>
<term>Stéatose hépatique non alcoolique (métabolisme)</term>
<term>Sérine-thréonine kinases TOR (MeSH)</term>
<term>Technique de Western (MeSH)</term>
<term>Transduction du signal (MeSH)</term>
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<term>Obesity</term>
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<term>Obesity</term>
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<term>Foie</term>
<term>Glycémie</term>
<term>Hépatocytes</term>
<term>Insuline</term>
<term>Obésité</term>
<term>Phosphoprotein Phosphatases</term>
<term>Protéine oncogène v-akt</term>
<term>Protéines à répétitions de séquences bêta-transducine</term>
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<term>Souris</term>
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<div type="abstract" xml:lang="en">Mechanistic target of rapamycin complex 1 (mTORC1), defined by the presence of Raptor, is an evolutionarily conserved and nutrient-sensitive regulator of cellular growth and other metabolic processes. To date, all known functions of Raptor involve its scaffolding mTOR kinase with substrate. Here we report that mTORC1-independent ('free') Raptor negatively regulates hepatic Akt activity and lipogenesis. Free Raptor levels in liver decline with age and in obesity; restoration of free Raptor levels reduces liver triglyceride content, through reduced β-TrCP-mediated degradation of the Akt phosphatase, PHLPP2. Commensurately, forced PHLPP2 expression ameliorates hepatic steatosis in diet-induced obese mice. These data suggest that the balance of free and mTORC1-associated Raptor governs hepatic lipid accumulation, and uncover the potentially therapeutic role of PHLPP2 activators in non-alcoholic fatty liver disease. </div>
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<Reference>
<Citation>Chem Rev. 2001 Aug;101(8):2365-80</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">11749378</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):17833-8</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">25453101</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell. 2002 Jul 26;110(2):163-75</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">12150925</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12753-8</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">12242332</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3155-60</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">12624180</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Mol Cell. 2003 Apr;11(4):895-904</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">12718876</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Diabetes. 2003 Dec;52(12):2905-13</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">14633850</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Science. 1998 Jan 30;279(5351):710-4</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">9445477</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Biol Chem. 1957 May;226(1):497-509</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">13428781</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Biochem J. 2005 Feb 1;385(Pt 3):639-48</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">15554902</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Science. 2005 Feb 18;307(5712):1098-101</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">15718470</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Mol Cell. 2005 Apr 1;18(1):13-24</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">15808505</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>JAMA. 2002 Jan 16;287(3):356-9</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">11790215</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Hepatology. 2005 Aug;42(2):473-80</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">15981216</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nat Rev Mol Cell Biol. 2006 Feb;7(2):85-96</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">16493415</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Ageing Res Rev. 2006 May;5(2):144-64</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">16630750</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Mol Cell. 2000 Jul;6(1):87-97</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">10949030</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Diabetes Obes Metab. 2001 Oct;3(5):367-80</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">11703427</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Biol Chem. 2006 Dec 8;281(49):37603-15</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">16971390</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Mol Cell. 2007 Mar 23;25(6):917-31</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">17386267</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Metabolism. 2007 Nov;56(11):1500-7</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">17950100</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Diabetologia. 2008 Mar;51(3):512-21</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18204829</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Metab. 2008 Jul;8(1):65-76</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18590693</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>EMBO J. 2008 Jul 23;27(14):1932-43</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18566586</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>EMBO J. 2008 Jul 23;27(14):1919-31</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18566587</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Metab. 2008 Sep;8(3):224-36</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18762023</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Biochem Biophys Res Commun. 2009 Jun 26;384(2):193-8</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19450723</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Biol Chem. 2009 May 29;284(22):15215-23</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19324870</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Mol Cell Biol. 2009 Dec;29(23):6192-205</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19797085</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3441-6</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20133650</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Mol Cell. 2010 Jun 11;38(5):768-74</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20542007</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Biol Chem. 2010 Jun 25;285(26):20109-16</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20427287</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Mol Cell. 2010 Jul 30;39(2):171-83</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20670887</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Circ Res. 2010 Aug 20;107(4):476-84</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20576936</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nature. 2010 Dec 23;468(7327):1100-4</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21179166</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Metab. 2011 Feb 2;13(2):215-21</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21284988</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Gastroenterology. 2011 Mar;140(3):1071-83</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21147110</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Trends Endocrinol Metab. 2011 Mar;22(3):94-102</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21269838</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Diabetologia. 2011 Jul;54(7):1879-87</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21461637</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Diabetes Obes Metab. 2011 Aug;13(8):692-702</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21449949</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Metab. 2011 Jul 6;14(1):9-19</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21723500</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Metab. 2011 Jul 6;14(1):21-32</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21723501</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell. 2011 Aug 5;146(3):408-20</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">21816276</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nat Med. 2012 Mar;18(3):388-95</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">22344295</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Metab. 2012 May 2;15(5):725-38</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">22521878</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Hepatology. 2012 Jun;55(6):1727-37</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">22183976</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Metab. 2012 Jun 6;15(6):873-84</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">22682225</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Biol Chem. 2012 Aug 24;287(35):29579-88</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">22773877</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Biol Chem. 2013 Apr 5;288(14):9572-82</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">23408427</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nat Med. 2013 Aug;19(8):1054-60</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">23832089</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>PLoS One. 2013;8(9):e75104</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">24069385</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Biomed Res Int. 2013;2013:382184</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">24286077</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Annu Rev Pharmacol Toxicol. 2014;54:537-58</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">24392697</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell. 2014 Feb 13;156(4):771-85</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">24529379</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nat Commun. 2014;5:5190</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">25307742</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Diabetes. 2015 Jun;64(6):1951-65</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">25576059</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
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